Key outcomes from the trip include Panama's commitment to exit China's Belt and Road Initiative and El Salvador's agreement to accept deportees of any nationality. Costa Rica pledged to expand cooperation with the U.S. against drugs, crime, and terrorism, while Guatemala committed to receiving 40% more deportation flights. The U.S. also assisted the Dominican Republic in seizing an aircraft belonging to a senior member of the Venezuelan regime, which was used to evade U.S. sanctions.

Rubio emphasized that these successes demonstrate the U.S.'s commitment to prioritizing its interests and those of its allies in the hemisphere. He contrasted the current administration's approach with that of the recent past, during which China's influence grew and several countries appeared to be turning away from the U.S. Rubio asserted that the "America First" agenda does not mean "America Alone," but rather a pragmatic approach based on realism and mutually beneficial deals with international partners.